Diabetic foot is known to be a severe long-term complication of diabetes. Although in the last years many improvements have been achieved, including a significant reduction of major amputation, ulcer recurrence and hospital readmission related to diabetic foot disease remain two current challenges for health care professionals operating in the field. Ulcer recurrence has been estimated to be 40% at 1 year after wound healing, and 60% at 3 years, while approximately 25% of patients admitted for diabetic foot problems require a new hospitalization after 6 months of follow-up. Ulcer recurrence and hospital re-admission are related to increased risk of non-healing, reduced quality of life and high cost for health care systems.