HFUS is a recently introduced diagnostic technique, which finds several applicationsin diverse clinical fields. It uses a range of frequencies higher than 20 MHz and provides a high spatial resolution, making this technique suitable for several clinical applications, such as imaging of skin, blood vessels, musculoskeletal anatomy, oral mucosa, and small parts.

Considering the many applications of HFUS in dermatology, we want to highlight its suitability in clinical evaluation of melanocytic lesions and non-proliferative diseases, which includes lichen sclerosus, morphea, sarcoidosis, hidradenitis suppurativa, chronic and acute wounds.

Moreover, HFUS may be useful in the evaluation of micro-vascularity, skin thickness modifications and skin structures modifications in systemic diseases (e.g., diabetes and Sjogren disease).